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Studii Brosura Pediatrie

Sistemul imunitar:

  1. First Defense
  • Składanowski, P. GolinskA, K Rudnicka, H. Dahm, M. Rai; Evaluation of cytotoxicity, immune compatibility and antibacterial activity of biogenic silver nanoparticles; Medical Microbiology and Immunology; December 2016, Volume 205, Issue 6, pp 603–61.
  • Yueh-Hsia Luo, Louis W. Chang, and Pinpin Lin; Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications; BioMed Research International; Volume 2015, Article ID 143720, 12 pages.
  • Morones-Ramirez, Jose Ruben, Winkler, Jonathan A., Spina, Catherine S., and Collins, James J. “Silver Enhances Antibiotic Activity Against Gram-Negative Bacteria.” Science Translational Medicine 2013 19 Jun; 5(190): 190ra81.
  • Massimiliano Francesco Peana, Valeria Marina Nurchi and Maria Antonietta Zoroddu, “ The medical uses of silver: history, myths and scientific evidence”, J. Med. Chem., DOI: 10.1021/acs.jmedchem.8b01439 • Publication Date (Web): 08 Feb 2019

Studii:

 

  1. Aller Care
  • Poonam Arora, S. H. Ansari, Abul Kalam Najmi, Varisha Anjum and Sayeed Ahmad; Investigation of anti-asthmatic potential of dried fruits of Vitis vinifera L. in animal model of bronchial asthma; Allergy, Asthma & Clinical Immunology2016.
  • Décio Medeiros Peixoto; José Angelo Rizzo; Deborah Schor; Almerinda Rêgo Silva; Dinaldo Cavalcanti de Oliveira; Dirceu Solé; Emanuel Sarinho; Use of honey associated with Ananas comosus (Bromelin) in the treatment of acute irritative cough; Revista Paulista de Pediatria; vol.34 no.4 São Paulo Oct./Dec. 2016

Studii:

 

  1. Zinc Plus & Zinc Gummy
  • Batool A. Haider and Zulfiqar A. Bhutta, “ The effect of therapeutic zinc supplementation among young children with selected infections: A review of the evidence”, Food and Nutrition Bulletin, vol. 30, no. 1 (supplement) © 2009, The United Nations University.
  • https://naturopathicpediatrics.com/2022/08/23
  • Wegmüller et al. (2014) Zinc Absorption by Young Adults from Supplemental Zinc Citrate Is comparable with That from Zinc Gluconate and Higher than from Zinc Oxide. J. Nutr. 144: 132–136, 2014.
  • Karrera Y. Djoko, Cheryl-lynn Y. Ong, Mark J. Walker and Alastair G. McEwan, The Role of Copper and Zinc Toxicity in Innate Immune Defense against Bacterial Pathogens*, THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 290, NO. 31, pp. 18954 –18961, July 31, 2015, © 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Published in the U.S.A.

Studii:

 

  1. Vitamina C 250 mg
  • Khalid Iqbal, Alam Khan et. al., "Biological Significance of Ascorbic Acid( Vitamin C) in Human Health- A Review", Pakistan Journal of Nutrition 3(1):5-13, 2004

Studii:

 

  1. Elderberry Super-Immune SoftChew Gummies™
  • Mohaddese Mahboubi, “ Sambucus nigra (black elder) as alternative treatment for cold and flu”, ADV TRADIT MED (ADTM). 2020 Jul 10 : 1–10.
  • Donald J. Cox, PhD, „ Introducing Wellmune®, an immune health ingredient”, Kerry Health and Nutrition Institute
  • Michalina Bartak, Agata Lange, Anna Słońska, Joanna Cymerys, “ Antiviral and healing potential of Sambucus nigra extracts”, Volumen 5 / Número 3, http://www.revistabionatura.com
  • https://khni.kerry.com/wp-content/uploads/2017/03/Introducing-Wellmune-an-immune-health-ingredient_FINAL.pdf

Studii:

 

  1. Colostrum with Probiotics & Colostrum with Probiotics Chewable Tabs
  • Kehoe S, Jayarao BM, Heinrichs A.; A survey of bovine colostrum composition and colostrum management practices on Pennsylvania dairy farms.; Journal of Dairy Science; 2007 Sep;90(9):4108-16.
  • Paulina Markowiak and Katarzyna Śliżewska; Effects of Probiotics, Prebiotics, and Synbiotics on Human Health; Nutrients. 2017 Sep; 9(9): 1021.
  • Harpal S.Buttar; Siddhi M.Bagwe; Sukhwinder K.Bhullar; GinpreetKaur; Chapter 1 - Health Benefits of Bovine Colostrum in Children and Adults; Dairy in Human Health and Disease Across the Lifespan; 2017, Pages 3-20.
  • Ivana Nikolic; Ivana Stojanovic; Milica Vujicic; Paolo Fagone; Katia Mangano; Stanislava Stosic-Grujicic; Ferdinando Nicoletti; Tamara Saksid, PhDa; Standardized bovine colostrum derivative impedes development of type 1 diabetes in rodents; Immunobiology; Volume 222, Issue 2, February 2017, Pages 272-279.

Studii:

  • Hałasa, M.; Skonieczna-Żydecka, K.; Machaliński, B.; Bühner, L.; Baśkiewicz-Hałasa, M. Six Weeks of Supplementation with Bovine Colostrum Effectively Reduces URTIs Symptoms Frequency and Gravity for Up to 20 Weeks in Pre-School Children. Nutrients2023, 15, 3626. https://doi.org/10.3390/nu15163626 https://www.mdpi.com/2072-6643/15/16/3626
  • Barakat SH, Meheissen MA, Omar OM, Elbana DA. Bovine Colostrum in the Treatment of Acute Diarrhea in Children: A Double-Blinded Randomized Controlled Trial. J Trop Pediatr. 2020 Feb 1;66(1):46-55. doi: 10.1093/tropej/fmz029. PMID: 31168590. https://pubmed.ncbi.nlm.nih.gov/31168590/

 

  1. Sambucus Immune Gummy

 

Sistemul Digestiv

  1. Jarro-Dophilus® Infant
  • Mark A. Underwood, J. Bruce German, Carlito B. Lebrilla and David A. Mills, ˝ Bifidobacterium longum subspecies infantis: champion colonizer of the infant gut˝, Pediatr Res. 2015 Jan; 77(0): 229–235.
  • Paulina Markowiak and Katarzyna Śliżewska; Effects of Probiotics, Prebiotics, and Synbiotics on Human Health; Nutrients. 2017 Sep; 9(9): 1021.

 

 

Studii:

 

  1. Baby + GOS
  • Paulina Markowiak and Katarzyna Śliżewska; Effects of Probiotics, Prebiotics, and Synbiotics on Human Health; Nutrients. 2017 Sep; 9(9): 1021.
  • https://www.morinagamilk.co.jp/english/research/r_and_d/bifidobacteria/
  • https://lallemand-health-solutions.com/en/
  • David Groeger, Liam O’Mahony, Eileen F. Murphy, John F. Bourke, Timothy G. Dinan, Barry Kiely, Fergus Shanahan, and Eamonn M.M. Quigley; Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut; Gut Microbes. 2013 Jul 1; 4(4): 325–339.

Studii:

  • Godínez-Méndez LA, Gurrola-Díaz CM, Zepeda-Nuño JS, Vega-Magaña N, Lopez-Roa RI, Íñiguez-Gutiérrez L, García-López PM, Fafutis-Morris M, Delgado-Rizo V. In Vivo Healthy Benefits of Galacto-Oligosaccharides from Lupinus albus(LA-GOS) in Butyrate Production through Intestinal Microbiota. Biomolecules. 2021 Nov 9;11(11):1658. doi: 10.3390/biom11111658. PMID: 34827656; PMCID: PMC8615603. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8615603/
  • Patole S, Keil AD, Chang A, Nathan E, Doherty D, Simmer K, Esvaran M, Conway P. Effect of Bifidobacterium breve M-16V supplementation on fecal bifidobacteria in preterm neonates--a randomised double blind placebo controlled trial. PLoS One. 2014 Mar 3;9(3):e89511. doi: 10.1371/journal.pone.0089511. PMID: 24594833; PMCID: PMC3940439. https://pubmed.ncbi.nlm.nih.gov/24594833/
  • Patole SK, Rao SC, Keil AD, Nathan EA, Doherty DA, Simmer KN. Benefits of Bifidobacterium breve M-16V Supplementation in Preterm Neonates - A Retrospective Cohort Study. PLoS One. 2016 Mar 8;11(3):e0150775. doi: 10.1371/journal.pone.0150775. PMID: 26953798; PMCID: PMC4783036. https://pubmed.ncbi.nlm.nih.gov/26953798/

 

 

  1. ChildBiotics™ Immune & Digestive Support

Studii:

  • Gerasimov SV, Ivantsiv VA, Bobryk LM, Tsitsura OO, Dedyshin LP, Guta NV, Yandyo BV. Role of short-term use of L. acidophilus DDS-1 and B. lactis UABLA-12 in acute respiratory infections in children: a randomized controlled trial. Eur J Clin Nutr. 2016 Apr;70(4):463-9. doi: 10.1038/ejcn.2015.171. Epub 2015 Oct 14. PMID: 26463725. https://pubmed.ncbi.nlm.nih.gov/26463725/
  • Gerasimov SV, Ivantsiv VA, Bobryk LM, Tsitsura OO, Dedyshin LP, Guta NV, Yandyo BV. Role of short-term use of L. acidophilus DDS-1 and B. lactis UABLA-12 in acute respiratory infections in children: a randomized controlled trial. Eur J Clin Nutr. 2016 Apr;70(4):463-9. doi: 10.1038/ejcn.2015.171. Epub 2015 Oct 14. PMID: 26463725 https://pubmed.ncbi.nlm.nih.gov/26463725/
  • Gan, D. et al. (2022) ‘Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial’, Frontiers in Microbiology, 13. doi:10.3389/fmicb.2022.985308, https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2022.985308/full

 

  1. Hepato-Care
  • Research analysis led by Kamal Patel; All content reviewed by the Examine.com Team. Published: Jun 13, 2014; Last Updated: Jun 14, 2018; https://examine.com/supplements/inositol/
  • Nora M. Griffiths , R. D. H. Stewart , Marion F. Robinson,"The metabolism of [75Se]selenomethionine in four women", Published online: 25 March 2008.
  • Flora K1, Hahn M, Rosen H, Benner K; Milk thistle (Silybum marianum) for the therapy of liver disease; American Journal of Gastroenterology; 1998 Feb;93(2):139-43.
  • Chan YS, Cheng LN, Wu JH, Chan E, Kwan YW, Lee SM, Leung GP, Yu PH, Chan SW; A review of the pharmacological effects of Arctium lappa (burdock); Inflammopharmacology. 2011 Oct;19(5):245-54. doi: 10.1007/s10787-010-0062-4. Epub 2010 Oct 28.
  • Assessment report on Taraxacum officinale Weber ex; Wigg., radix cum herba; 12 November 2009; EMA/HMPC/212897/2008; Committee on Herbal Medicinal Products (HMPC).
  • Asghar Farghi Yamchi; Mansour Dabirzadeh; Abdolhossein Miri; Effects of Methanolic Extract of Arctium lappa Root on Promastigotes and Amastigotes of Leishmania major (in vitro); September 2016 with 24 Reads; DOI: 10.18869/acadpub.mlj.10.5.50.

Studii:

 

  1. Para Defense
  • Mohamed Fizur Nagoor Meeran,Hayate Javed et. Al., " Pharmacological Properties and Molecular Mechanisms of Thymol: Prospects for Its Therapeutic Potential and Pharmaceutical Development", Front Pharmacol. 2017; 8: 380.
  • Eqbal M. A. Dauqan, Aminah Abdullah, " Medicinal and Functional Values of Thyme (Thymus vulgaris L.) Herb", Journal of Applied Biology & Biotechnology Vol. 5 (02), pp. 017-022, March-April, 2017
  • Maciej Grzybek, Wirginia Kukula-Koch et. al., ˝Evaluation of Anthelmintic Activity and Composition of Pumpkin (Cucurbita pepo L.) Seed Extracts—In Vitro and in Vivo Studies˝, Int. J. Mol. Sci. 2016, 17(9), 1456; doi:10.3390/ijms17091456
  • Jing-Yang Wong, Mahmood Ameen Abdulla et. al., ˝Gastroprotective Effects of Lion’s Mane Mushroom Hericium erinaceus (Bull.:Fr.) Pers. (Aphyllophoromycetideae) Extract against Ethanol-Induced Ulcer in Rats˝, Evidence-Based Complementary and Alternative Medicine, Volume 2013, Article ID 492976
  • Leyla Bayan, Peir Hossain Koulivand and Ali Gorji, " Garlic: a review of potential therapeutic effects", Avicenna J Phytomed. 2014 Jan-Feb; 4(1): 1–14
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7767362 Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials
  • https://pubmed.ncbi.nlm.nih.gov/16390816/doi: 10.1080/10611860500422958. Antimicrobial activity of clove oil and its potential in the treatment of vaginal candidiasis
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9147557/ O perspectivă concentrată asupra cimbrului: proprietăți biologice, chimice și terapeutice ale unei ierburi mediteraneene indigene
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405664/ Revizuirea proprietăților farmacologice și a constituenților chimici ai Pimpinella anisum

Studii:  https://smujo.id/jnpb/article/view/2086/1961

 

  1. Gripe Water
  • Shanthi G. Parkar, Doug Rosendale et. al., ‘’In vitro Utilization of Gold and Green Kiwifruit Oligosaccharides by Human Gut Microbial Populations’’, Plant Foods for Human Nutrition, September 2012, Volume 67, Issue 3, pp 200–207.
  • Irina Alexandrovich, Olga  Rakovitskaya et. al., ‘’ The effect of fennel (Foeniculum vulgare) seed oil emulsion in infantile colic: A randomized, placebo-controlled study’’, Alternative Therapies in Health and Medicine; Aliso Viejo Vol. 9, Iss. 4,  (Jul/Aug 2003): 58-61.

 Studii:

  • Kaur, L., Rutherfurd, SM, Moughan, PJ, Drummond, L. și Boland, MJ (2010). Actinidina îmbunătățește digestia proteinelor gastrice, așa cum a fost evaluată folosind un model de digestie gastrică in vitro. Journal of Agricultural and Food Chemistry, 58(8), 5068–5073. doi:10.1021/jf903332a

 

  1. Synergize-Your-Gut®

 

 

 

Sistemul nervos:

  1. Cod liver Oil & Pure DHA
  • Studii observaţionale efectuate în 2010-2011 în cadrul Spitalului Clinic de Urgenţă pentru copii “Grigore Alexandrescu”, Bucureşti, România:

Efectele produsului Cod Liver Oil (ChildLife® Essentials) ca adjuvant al corticoterapiei în afecţiunile autoimune: lupus eritematos sistemic şi artrita reumatoidă juvenil.

Efectele produsului Cod Liver Oil (ChildLife® Essentials) în tratamentul complementar al infecţiilor cu virusurile hepatice B şi C, cu sau fără citoliză.

Studii:

  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7468918/
  • Eduardo Javier Barragan-Perez et.al., “Effectiveness of the Use of an Omega-3 and Omega-6 Combination (Equazen™) in Paediatric Patients with Refractory Epilepsy”, Epilepsy Clin Neurophysiol 2011;17(4):148-15.
  • Clare M.Eddyet et. Al, “The cognitive impact of antiepileptic drugs”, Ther Adv Neurol Disord.
  • Ijff D.M.et al., “ Cognitive side effects of antiepileptic drugs in children”, HandbClin Neurol. 2013.

 

  1. Sleep essentials

Studii:

  • Boafo A, Greenham S, Alenezi S, Robillard R, Pajer K, Tavakoli P, De Koninck J. Could long-term administration of melatonin to prepubertal children affect timing of puberty? A clinician's perspective. Nat Sci Sleep. 2019 Jan 31;11:1-10. doi: 10.2147/NSS.S181365. PMID: 30774488; PMCID: PMC6362935. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362935/  
  • Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011 Dec;16(4):348-54. PMID: 22214254. https://pubmed.ncbi.nlm.nih.gov/22214254/

 

Sistemul Respirator:

  1. Echinacea copii
  • Joanne Barnes, Linda A. Anderson, Simon Gibbons and J. David Phillipson, "Echinacea species (Echinacea angustifolia (DC.) Hell.,Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.)Moench): a review of their chemistry, pharmacology and clinical properties", Journal of Pharmacy and Pharmacology, JPP 2005, 57: 929–954.

Studii:

 

  1. Organic liquid elderberry
  • Mohaddese Mahboubi, “ Sambucus nigra (black elder) as alternative treatment for cold and flu”, ADV TRADIT MED (ADTM). 2020 Jul 10 : 1–10.
  • Andrzej Sidor, Anna Gramza-Michałowska, “ Advanced research on the antioxidant and health benefit of elderberry (Sambucus nigra) in food – a review”, Journal of Functional Foods Volume 18, Part B, October 2015, Pages 941-958

Studiu:

  • Della Volpe A, Ricci G, Ralli M, Gambacorta V, De Lucia A, Minni A, Pirozzi C, Paccone M, Pastore V, Di Stadio A. The effects of oral supplements with Sambucus nigra, Zinc, Tyndallized Lactobacillus acidophilus (HA122), Arabinogalactans, vitamin D, vitamin E and vitamin C in otitis media with effusion in children: a randomized controlled trial. Eur Rev Med Pharmacol Sci. 2019 Jul;23(14):6360-6370. doi: 10.26355/eurrev_201907_18460. PMID: 31364144. https://pubmed.ncbi.nlm.nih.gov/31364144/

 

  1. Cough syrup
  • Pharmacodynamic Basis of Herbal Medicine Second Edition; Manuchair Ebadi; CRC Press, 6 sept. 2006 - 699 pagini; pg. 137-138.
  • David Hoffmann, FNIMH, AHG; Medical Herbalism, The Science and Practice of Herbal Medicine; pg. 575, 580, 2003.
  • Herbal approaches to system dysfunctions; Principles and Practice of Phytotherapy (Second Edition); Modern Herbal Medicine; 2013, Pages 183-350.

Studiu:  

 

  1. Cold-Care Cough Syrup & Cold-Care Hot Drink

 

 

Sistemul osos:

  1. Calcium with Magnesium
  • Jan Philipp Schuchardt and Andreas Hahn; Intestinal Absorption and Factors Influencing Bioavailability of Magnesium-An Update; Current Nutrition and Food Science; 2017 Nov; 13(4): 260–278.
  • Hanzlik RP, Fowler SC, Fisher DH.; Relative bioavailability of calcium from calcium formate, calcium citrate, and calcium carbonate; J Pharmacol Exp Ther. 2005 Jun;313(3):1217-22. Epub 2005 Feb 25.
  • Barrie SA, Wright JV, Pizzorno JE, Kutter E, Barron PC.; Agents Actions. 1987 Jun;21(1-2):223-8.; Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans.

Studii:

 

  1. Vitamin D3 500 UI & Vitamin D3 Gummy

Studii:

 

  1. Vitamin K2
  • Leon J. Schurgers, Kirsten J. F. Teunissen et. al., ‘’Vitamin K–containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7’’, The American Society of Hematology, 2007
  • Gerry Kurt Schwalfenberg, " Vitamins K1 and K2: The Emerging Group of Vitamins Required for Human Health", J Nutr Metab. 2017; 2017: 6254836.
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8774117/ Impactul vitaminei K2 (Menaquionone) în sănătatea și bolile copiilor: o revizuire a literaturii

Studii:

  • Ling Liu, Chao-Hong Chen, Shi-Wen Rong, Shao-Zhu Lin, Na-Li Cai, Dang Ao, Antenatal steroid as an independent risk factor for vitamin K2 deficiency in newborns, Saudi Medical Journal Aug 2023, 44 (8) 788-794; DOI:15537/smj.2023.44.8.20230084 https://smj.org.sa/content/44/8/788

 

Dezvoltare generala:

  1. Multi Vitamin & Mineral & Alive!® Kids Multivitamin Gummy 60

 

  1. Liquid Iron 10 mg
  • ‘’Ferrous bisglycinate as a source of iron for use in the manufacturing of foods and in food supplements’’, The EFSA Journal (2006) 299, 1-17.
  • Seria Protocoale în îngrijirea anemiei și rahitismului la copil, Ministerul Sănătății, Institutul pentru Ocrotirea Mamei și Copilului, ‘’Prof. Dr. Alfred Rusescu’’.
  • https://www.synevo.ro/shop/feritina/

Studii:

  • Mahmoud A. El-Hawy, Sohyla A. Abd Al-Salam, Wael A. Bahbah,Comparing oral iron bisglycinate chelate, lactoferrin, lactoferrin with iron and iron polymaltose complex in the treatment of children with iron deficiency anemia,Clinical Nutrition ESPEN, Volume 46,2021,Pages 367-371,ISSN 2405-4577, https://doi.org/10.1016/j.clnesp.2021.08.040

 

  1. Healthy Vision SoftMelts™
  • Keyvan Koushan, Raluca Rusovici, Wenhua Li, Lee R. Ferguson, and Kakarla V. Chalam. The Role of Lutein in Eye-Related Disease. Nutrients. 2013 May; 5(5): 1823–1839.
  • Justyna Widomska , John Paul SanGiovanni, and Witold K. Subczynski. Why Is Zeaxanthin the Most Concentrated Xanthophyll in the Central Fovea? Published: 7 May 2020
  • Tatania K. Emmick and Diane Alexander, Ph.D. Why Dietary Zeaxanthin? - A Scientific Summary. Kemin Industries, Inc. and its group of companies 2013.
  • Silvio Buscemi, Davide Corleo, Francesco Di Pace, Maria Letizia Petroni, Angela Satriano, and Giulio Marchesini. The Effect of Lutein on Eye and Extra-Eye Health. Nutrients. 2018 Sep; 10(9): 1321.
  • Kvansakul J, Rodriguez-Carmona M, Edgar DF, Barker FM, Köpcke W, Schalch W, Barbur JL; Supplementation with the carotenoids lutein or zeaxanthin improves human visual performance; Ophthalmic Physiol Opt. 2006 Jul;26(4):362-71.
  • https://www.ebmconsult.com/articles/vitamin-a-eye-vision-mechanism
  • Seong Hee Shim, Joon Mo Kim, Chul Young Choi, Chan Yun Kim, and Ki Ho Park. Ginkgo biloba Extract and Bilberry Anthocyanins Improve Visual Function in Patients with Normal Tension Glaucoma. J Med Food. 2012 Sep; 15(9): 818–823.

Studii: