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(3) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9662251/

(4) https://onlinelibrary.wiley.com/doi/10.1111/cns.13207

(5) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568373/

(6) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037471/

(7) https://www.sciencedirect.com/science/article/abs/pii/B9780123750839002464

(8) https://www.ncbi.nlm.nih.gov/books/NBK541036/

(9) https://www.mdpi.com/1422-0067/20/4/974

(10) https://pubmed.ncbi.nlm.nih.gov/31691401/

(11) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358464/

(12) https://www.mdpi.com/2227-9059/11/9/2578

(13) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386534/

(14) https://www.medicalnewstoday.com/articles/287720#benefits

(15) https://lpi.oregonstate.edu/mic/vitamins/biotin

(16) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3218540/

(17) https://www.health.com/vitamin-b12-7252832

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(18) BirgitHolst, GaryWilliamson, " Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants",

Current Opinion in Biotechnology, Volume 19, Issue 2, April 2008, Pages 73-82.

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AND PHARMACOLOGICAL ACTIVITIES", EXCLI Journal 2015;14:59-63 – ISSN 1611-2156.

(20) Dinesh Kumar; Vikrant Arya; Zulfiqar Ali Bhat; Nisar Ahmad Khan; Deo Nandan Prasad; The genus Crataegus: chemical and pharmacological perspectives; Rev. bras. farmacogn. vol.22 no.5 Curitiba Sept./Oct. 2012 Epub Aug 16, 2012.

(21) Hai-Rong Yu, Yu-Lian Jiang, Dan-Dan Dong, Guo-Hong Wang; Cardioprotective effects of the total flavonoids of Polygonum cuspidatum Sieb. et Zucc. Root extract on experimental myocardial infarction in mice; Tropical Journal of Pharmaceutical Research; Vol 18, No 2 (2019).

(22) Abhinav Sharma , Gregg C. Fonarow , Javed Butler , Justin A. Ezekowitz , and G. Michael Felker; Coenzyme Q10 and Heart Failure, A State-of-the-Art Review; Vol. 9, No. 4; Originally published24 Mar 2016.

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(18) BirgitHolst, GaryWilliamson, " Nutrients and phytochemicals: from bioavailability to bioefficacy beyond antioxidants",

Current Opinion in Biotechnology, Volume 19, Issue 2, April 2008, Pages 73-82.

(19) Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu et. Al., " AN UP-TO-DATE REVIEW OF RUTIN AND ITS BIOLOGICAL

AND PHARMACOLOGICAL ACTIVITIES", EXCLI Journal 2015;14:59-63 – ISSN 1611-2156.

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(23) https://www.e-tyh.com/assets/images/PDF/Alpha%20Lipoic%20Energy.pdf

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(26) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926869/

(27) https://www.sciencedirect.com/science/article/abs/pii/S1382668913002251

(28) https://pubmed.ncbi.nlm.nih.gov/17476591/

(29) https://www.sciencedirect.com/science/article/abs/pii/S0891584901005512-

(30) https://pubmed.ncbi.nlm.nih.gov/34026086/

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(32) https://www.ncbi.nlm.nih.gov/books/NBK591554/LiverTox

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(34) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967105/

(35) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446120/

(36) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013587/

(37) https://pubmed.ncbi.nlm.nih.gov/32621549/

(38) https://pubmed.ncbi.nlm.nih.gov/27840374/

(39) https://pubmed.ncbi.nlm.nih.gov/27665784/

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(42) https://dmsjournal.biomedcentral.com/articles/10.1186/17

(43) https://pubmed.ncbi.nlm.nih.gov/34026086/

(44) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9774895/

(45) https://jarrow.com/products/alpha-lipoic-sustain-tablets?_pos=1&_sid=b706f35e3&_ss=r

(46) https://examine.com/supplements/biotin/#nutrient-nutrient-interactions_lipoic-acid

(47) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3570162/

(48) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9197635/

(49) https://www.sparrow.org/departments-conditions/conditions/peripheral-neuropathy

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(1) Lesley Braun, Marc Cohen; Herbs and Natural Supplements; An evidence-based guide, 3rd Edition; Churchill Livingstone, Elsevier, 2010; pg. 256-262; Black cohosh.

(38) https://l-theanine.com/awards/

(39) https://produccioncientifica.ucm.es/documentos/601df5a4ecc73607262a1cc9?lang=en

(40) https://www.ncbi.nlm.nih.gov/books/NBK538260/

(41) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321452/

(42) https://www.ncbi.nlm.nih.gov/books/NBK279054/

(43) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798480/

(44) https://www.sciencedirect.com/science/article/abs/pii/S0378512209002631

(45) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433670/

(46) https://repub.eur.nl/pub/32018/021023_Colin,%20Edgar%20Merfyn.pdf

(47) https://www.pearlrejuvenation.com/the-truth-about-estrogen-and-the-skin/

(48) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864699/

(49) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390141/

(50) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834516/

(51) https://www.clearblue.com/menopause/what-to-expect-in-perimenopause

(52) https://www.meno-me.com/what-is-estrogen-dominance/

(53) https://www.mayoclinic.org/diseases-conditions/perimenopause/symptoms-causes/syc-20354666

(54) https://banksnutrition.com/hormone-imbalance

(55) https://www.healthline.com/nutrition/vitex#womens-reproduction

(56) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865197/

(57) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508121/

(58) https://onlinelibrary.wiley.com/doi/10.1046/j.1523-5408.2002.05603.x

(59) https://doi.org/10.1016/j.phrs.2008.05.008

(60) https://www.ingentaconnect.com/content/ben/cpd/2017/00000023/00000019/art00012

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(64) https://www.liebertpub.com/doi/10.1089/jmf.2020.4803

(65) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228580/

(66) https://onlinelibrary.wiley.com/doi/full/10.1155/2022/5647599

(67) https://www.liebertpub.com/doi/abs/10.1089/9781934854051.154

(68) https://pubmed.ncbi.nlm.nih.gov/27581807/

(69) https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-022-00664-6

(70) https://pubmed.ncbi.nlm.nih.gov/35732671/

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(72) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8406948/

(73) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292526/

(74) https://www.mdpi.com/1424-8247/15/3/278

(75) https://www.warddeanmd.com/hormone-replacement-alternatives-for-women/

(76) https://www.nhs.uk/medicines/hormone-replacement-therapy-hrt/side-effects-of-hormone-replacement-therapy-hrt/

(77) https://www.tandfonline.com/doi/full/10.2147/CCID.S333663#d1e700

(78) https://www.sciencedirect.com/science/article/pii/S1744388122000834

(79) https://www.ncbi.nlm.nih.gov/books/NBK279311/

(80) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3634232/

(81) https://pubmed.ncbi.nlm.nih.gov/29460096/

(82) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466056/

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(1) Lesley Braun, Marc Cohen; Herbs and Natural Supplements; An evidence-based guide, 3rd Edition; Churchill Livingstone, Elsevier, 2010; pg. 256-262; Black cohosh.

(38) https://l-theanine.com/awards/

(39) https://produccioncientifica.ucm.es/documentos/601df5a4ecc73607262a1cc9?lang=en

(40) https://www.ncbi.nlm.nih.gov/books/NBK538260/

(41) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321452/

(42) https://www.ncbi.nlm.nih.gov/books/NBK279054/

(43) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9798480/

(44) https://www.sciencedirect.com/science/article/abs/pii/S0378512209002631

(45) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433670/

(46) https://repub.eur.nl/pub/32018/021023_Colin,%20Edgar%20Merfyn.pdf

(47) https://www.pearlrejuvenation.com/the-truth-about-estrogen-and-the-skin/

(48) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864699/

(49) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390141/

(50) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834516/

(51) https://www.clearblue.com/menopause/what-to-expect-in-perimenopause

(52) https://www.meno-me.com/what-is-estrogen-dominance/

(53) https://www.mayoclinic.org/diseases-conditions/perimenopause/symptoms-causes/syc-20354666

(54) https://banksnutrition.com/hormone-imbalance

(55) https://www.healthline.com/nutrition/vitex#womens-reproduction

(56) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865197/

(57) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5508121/

(58) https://onlinelibrary.wiley.com/doi/10.1046/j.1523-5408.2002.05603.x

(59) https://doi.org/10.1016/j.phrs.2008.05.008

(60) https://www.ingentaconnect.com/content/ben/cpd/2017/00000023/00000019/art00012

(61) https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/1600342419.pdf

(62) https://journals.sagepub.com/doi/full/10.1177/1534735413477191

(63) https://onlinelibrary.wiley.com/doi/full/10.1111/jmwh.12628?casa_token=Tm-EObSraQcAAAAA%3A5xRPILs6xUlYV8LcKJcyAFNZe_DfP9uwO49b8cY_RuQor1j7q1TN2NAnU4mcwWeq4LiK218R734TSw

(64) https://www.liebertpub.com/doi/10.1089/jmf.2020.4803

(65) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9228580/

(66) https://onlinelibrary.wiley.com/doi/full/10.1155/2022/5647599

(67) https://www.liebertpub.com/doi/abs/10.1089/9781934854051.154

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(73) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292526/

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(77) https://www.tandfonline.com/doi/full/10.2147/CCID.S333663#d1e700

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87. https://examine.com/supplements/ashwagandha/

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101. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8762185/

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105. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9701317/

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(17) Eliana Noelia Alonso, María Julia Ferronato, Norberto Ariel Gandini, María Eugenia Fermento, Diego Javier Obiol, Alejandro López Romero, Julián Arévalo, María Emilia Villegas, María Marta Facchinetti & Alejandro Carlos Curino; Antitumoral Effects of D-Fraction from Grifola Frondosa (Maitake) Mushroom in Breast Cancer; Journal of Nutrition and Cancer; Volume 69, 2017 - Issue 1; Pages 29-43 | Received 26 Nov 2015, Accepted 04 Aug 2016, Published online: 28 Nov 2016.

(18) Xirui He, Xiaoxiao Wang, Jiachen Fang, Yu Chang, Ning Ning, Hao Guo, Linhong Huan, Xiaoqiang Huang, Zefeng Zhao; Polysaccharides in Grifola frondosa mushroom and their health promoting properties: A review; International Journal of Biological Macromolecules; Volume 101, August 2017, Pages 910-921.

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(51) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6271637/

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(53) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504980/

(54) https://www.sciencedirect.com/science/article/pii/S0753332222015190

(55) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5584359/

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56. https://mcpress.mayoclinic.org/nutrition-fitness/magnesium-glycinate-is-this-supplement-helpful-for-you/

57. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637834/

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59. Lisa A. Yablon and Alexander Mauskop, ˝ Magnesium in headache˝, Magnesium in the Central Nervous System, Adelaide (AU): University of Adelaide Press; 2011.

60. Magdalena D. Cuciureanu and Robert Vink, ˝ Magnesium and stress˝, Magnesium in the Central Nervous System, Adelaide (AU): University of Adelaide Press; 2011.

36. https://www.sciencedirect.com/science/article/pii/B9780124201682000314

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5.Evert Boonstra, Roy de Kleijn et. al., "Neurotransmitters as food supplements: the effects of GABA on brain and behavior", Front Psychol. 2015; 6: 1520.

77.Ruchi Tiwari, Sandip Chakraborty et. Al., "Ashwagandha (Withania somnifera): Role in Safeguarding Health, Immunomodulatory Effects, Combating Infections and Therapeutic Applications: A Review", Journal of Biological Sciences, Volume 14 (2): 77-94, 2014

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81.https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/melissa-officinalis

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1. The psyllium gel is not fermented and transits the entire gastrointestinal tract intact. – NursingCenter / Journal of WOCN, 2021

2. How does psyllium work? – Examine.com, actualizat 2023

3. Psyllium provides lubrication that facilitates propulsion of colon contents and produces a stool that is bulkier and more moist. – American Journal of Medicine / ScienceDirect, 2023

4. Why does magnesium oxide work as a laxative? – Medshun Health Resource, 2023

5. Magnesium oxide in clinical practice: osmotic effect and safety. – European Journal of Clinical Pharmacology (SpringerLink), 2014

6. Experts Recommend 2 New Treatments for Constipation. – Verywell Health, 2023

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45. https://www.sciencedirect.com/science/article/pii/S1756464614002400

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55. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037471/

56. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8880174/

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61. https://www.hindawi.com/journals/isrn/2013/898125/ The Pleiotropic Effect of Vitamin D (2013)

62. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688475/ Vitamin D and Bone (2013)

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66.https://pubmed.ncbi.nlm.nih.gov/26055108/#:~:text=New%20insights%20into%20the%20biology%20of%20osteocalcin New insights into the biology of osteocalcin (2016)

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68. https://pubmed.ncbi.nlm.nih.gov/30791399/Vitamin K: Double Bonds beyond Coagulation Insights into Differences between Vitamin K1 and K2 in Health and Disease (2019)

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124. https://www.endocrine.org/clinical-practice-guidelines/vitamin-d-for-prevention-of-disease Vitamin D for the Prevention of Disease Guideline Resources (2024)

125. https://my.clevelandclinic.org/health/diseases/15050-vitamin-d-vitamin-d-deficiency Vitamin D Deficiency

126. https://ods.od.nih.gov/factsheets/VitaminE-HealthProfessional/ Vitamin E

127. https://menaq7.com/science-2/

128. https://www.mdpi.com/2072-6643/15/3/480 Vitamin D and Bone: A Story of Endocrine and Auto/Paracrine Action in Osteoblasts (2023)

129. https://pmc.ncbi.nlm.nih.gov/articles/PMC7192829/ Vitamin D-Cathelicidin Axis: at the Crossroads between Protective Immunity and Pathological Inflammation during Infection (2020)

130. https://pubmed.ncbi.nlm.nih.gov/26257123/ 1,25-Dihydroxy-vitamin D3 regulates NK-cell cytotoxicity, cytokine secretion, and degranulation in women with recurrent pregnancy losses (2015)

131. https://pmc.ncbi.nlm.nih.gov/articles/PMC5318626/ Vitamin D Status and Its Association with Parathyroid Hormone Concentration in Brazilians (2017)

132. https://www.mdpi.com/1422-0067/21/23/9296 Policing Cancer: Vitamin D Arrests the Cell Cycle (2020)

133. https://www.sciencedirect.com/topics/food-science/cholecalciferol – Cholecalciferol: Properties and Determination (2016)

134. https://lpi.oregonstate.edu/es/mic/vitaminas/vitamina-E

135. https://pmc.ncbi.nlm.nih.gov/articles/PMC4670816/

New Insights into the Biology of Osteocalcin (2015)

DAO Enzyme

1. Intoleranța la histamină: acumulare excesivă de histamină din cauza deficitului DAO – caracterizare clinică și rolul DAO. Revista Sanitaria de Investigación, 2025.

2. Observații privind suplimentarea orală cu DAO și ameliorarea simptomelor HIT. Clinical Nutrition ESPEN, 2023 (studiu observațional).

3. Utilizarea DAO ca tool de diagnostic – analiza activității enzimatice la populație mare. Nutrients, 2023 (MDPI).

4. Trial randomizat, dublu-orb / protocoale recente privind suplimentarea cu DAO. Nutrients, 2025 (protocol); preprint fază I (medRxiv, 2024).

5. Kinetic study: dozare progresivă a DAO vegetal în intoleranță histaminică (registru studii clinice, 2024).

6. Metabolismul histaminei: rolul DAO vs. HNMT (prezentare generală).

7. DAO – rol fiziologic digestiv și în inflamație (sinteză generală).

8. Trial clinic observațional DAO – ameliorare simptome digestive (sursă informativă).

9. Perspective clinice – intoleranță la histamină vs. alergii (articol informativ).

10. Maintz L., Novak N. Histamine and histamine intolerance. Am J Clin Nutr. 2007.

11. Schwelberger H.G. Histamine intolerance: a metabolic disease? Inflamm Res. 2010.

12. Comas-Basté O., et al. Histamine intolerance: the current state of the art. Biomolecules. 2020.

13. Reese I., Ballmer-Weber B.K., Beyer K., et al. Guidelines for the management of histamine intolerance. Allergo J Int. 2017.

Echinacea Angustifolia 125mg

(7) Joanne Barnes, Linda A. Anderson, Simon Gibbons and J. David Phillipson, "Echinacea species (Echinacea angustifolia (DC.) Hell.,Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.)Moench): a review of their chemistry, pharmacology and clinical properties", Journal of Pharmacy and Pharmacology, JPP 2005, 57: 929–954.

(74) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362099/ - Îmbunătățirea funcțiilor imune înnăscute și adaptative de către mai multe specii de echinacea

(75) https://www.sciencedirect.com/science/article/pii/S2589936821000396 - O revizuire sistematică a efectelor suplimentării cu Echinacea asupra nivelurilor de citokine: Există un rol în COVID-19?

(76) https://www.sciencedirect.com/science/article/pii/S1043661823003079 Echinacozida: Un produs natural activ promițător și agenți farmacologici

Energy Magnesium Powder Pineapple 252g pudra

56. https://mcpress.mayoclinic.org/nutrition-fitness/magnesium-glycinate-is-this-supplement-helpful-for-you/

57. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637834/

30. https://examine.com/supplements/schisandra-chinensis/research

28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208354/

29. https://examine.com/supplements/rhodiola-rosea/research/

35. https://www.acog.org/patient-resources/faqs/gynecologic-problems/premenstrual-syndrome

25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637834/

58. https://www.tandfonline.com/doi/full/10.1080/1028415X.2021.1945859?casa_token=SDQ7LdNV9ToAAAAA%3AMuEZr-vVumKWLUehTrOB9XpKKmobXbAUQlaJDTbzeR9gPu78lgNUgWj8ac9YM3JNxbTNuKyn5rOPWJOb

59. Lisa A. Yablon and Alexander Mauskop, ˝ Magnesium in headache˝, Magnesium in the Central Nervous System, Adelaide (AU): University of Adelaide Press; 2011.

60. Magdalena D. Cuciureanu and Robert Vink, ˝ Magnesium and stress˝, Magnesium in the Central Nervous System, Adelaide (AU): University of Adelaide Press; 2011.

36. https://www.sciencedirect.com/science/article/pii/B9780124201682000314

61. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3703169/

62. https://pubmed.ncbi.nlm.nih.gov/8509592/

63. https://pubmed.ncbi.nlm.nih.gov/28392498/

64. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045762/

65. https://www.sciencedirect.com/science/article/abs/pii/S875632822100048X

66. https://pubmed.ncbi.nlm.nih.gov/17063625/

67. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8313472/

68. https://www.ncbi.nlm.nih.gov/books/NBK541123/

69. https://www.mdpi.com/2072-6643/13/11/4074

70. https://www.mdpi.com/2072-6643/13/4/1136

71. https://pubmed.ncbi.nlm.nih.gov/18516713/

72. https://www.sciencedirect.com/science/article/pii/S2213231722000854

73. https://www.sciencedirect.com/science/article/abs/pii/S0272638612806676

Good-Aging

1. https://europa.eu/eurobarometer/surveys/detail/

2. https://sinclair.hms.harvard.edu/people/david-sinclair

3. https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1359176/full Apigenin: a natural molecule at the intersection of sleep and aging (2024)

4. https://pmc.ncbi.nlm.nih.gov/articles/PMC6472148/ The Therapeutic Potential of Apigenin (2019)

5. https://pmc.ncbi.nlm.nih.gov/articles/PMC8289612/

6. https://pmc.ncbi.nlm.nih.gov/articles/PMC10722989/ Exploring the anti-aging effects of fisetin in telomerase-deficient progeria mouse model (2023)

7. https://www.sciencedirect.com/science/article/pii/S0047637424000952 Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases (2024)

8. https://www.sciencedirect.com/science/article/abs/pii/S004763741300050X The autophagy enhancer spermidine reverses arterial aging (2013)

9. https://hal.science/hal-04702724v1/document Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? (2019)

10. https://pmc.ncbi.nlm.nih.gov/articles/PMC8612618/ New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases (2021)

11. https://pmc.ncbi.nlm.nih.gov/articles/PMC8389214/ Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation (2021)

12. https://www.maturitas.org/article/S0378-5122(24)00186-5/fulltext The impact of carnosine on biological ageing – A geroscience approach (2024)

13. https://pubmed.ncbi.nlm.nih.gov/29858687/ Carnosine and advanced glycation end products: a systematic review (2018)

14. https://pmc.ncbi.nlm.nih.gov/articles/PMC3836174/ The Hallmarks of Aging (2013)

15. https://pubmed.ncbi.nlm.nih.gov/29185343/ Pyrroloquinoline Quinone, a Redox-Active o-Quinone, Stimulates Mitochondrial Biogenesis by Activating the SIRT1/PGC-1α Signaling Pathway (2017)

16.https://academic.oup.com/carcin/article-abstract/33/1/149/2463617?redirectedFrom=fulltext&login=false Resveratrol protects mouse embryonic stem cells from ionizing radiation by accelerating recovery from DNA strand breakage (2011)

17. https://cajmhe.com/index.php/journal/article/view/48 Spermidine maintains telomere length and delays aging (2021)

18. https://pmc.ncbi.nlm.nih.gov/articles/PMC5791748/ Plant flavone apigenin: An emerging anticancer agent (2017)

19. https://www.sciencedirect.com/science/article/abs/pii/S1567576911001512 Anti-inflammatory activity of

20. https://pmc.ncbi.nlm.nih.gov/articles/PMC7350017/ Genome-Protecting Compounds as Potential Geroprotectors (2020)

21. https://pmc.ncbi.nlm.nih.gov/articles/PMC3746174/ Sirtuin 1 and sirtuin 3: physiological modulators of metabolism (2013)

22. https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/spermidine

Spermidine (2022)

23. https://karger.com/cpb/article/49/5/1870/76372/Fisetin-Protects-Against-Hepatic-Steatosis-Through

Fisetin Protects Against Hepatic Steatosis Through Regulation of the Sirt1/AMPK and Fatty Acid β-Oxidation Signaling Pathway in High-Fat Diet-Induced Obese Mice (2018)

24. https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14706

25. https://www.mgcpqq.eu/about/ MGCPQQ

26. https://www.sciencedirect.com/science/article/abs/pii/S0141813023014757 A pharmacological review on SIRT 1 and SIRT 2 proteins, activators, and inhibitors: Call for further research (2023)

27. https://pmc.ncbi.nlm.nih.gov/articles/PMC11078917/ An overview on glycation: molecular mechanisms, impact on proteins, pathogenesis, and inhibition (2024)

28. https://www.mdpi.com/2073-4409/12/23/2742 Unraveling the Intricacies of Autophagy and Mitophagy: Implications in Cancer Biology (2023)

29. https://pmc.ncbi.nlm.nih.gov/articles/PMC8448505 Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition (2016))

30. https://onlinelibrary.wiley.com/doi/10.1002/mc.20793 Apigenin, a chemopreventive bioflavonoid, induces AMP-activated protein kinase activation in human keratinocytes (2011)

31. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5737637/ NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism (2018)

32. https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2024.1393181/full SIRT1, resveratrol and aging (2024)

33. https://www.hubermanlab.com/topics/aging-and-longevity

34. https://pubmed.ncbi.nlm.nih.gov/38421057/ Efectele terapeutice ale resveratrolului asupra mecanismelor epigenetice în bolile legate de vârstă: o analiză cuprinzătoare

35. https://pmc.ncbi.nlm.nih.gov/articles/PMC4632807/ Modificări ale capacității regenerative pe parcursul vieții

36. https://pmc.ncbi.nlm.nih.gov/articles/PMC9068308/Intervenții nutriționale ale compușilor din plante asupra senescenței celulare

37.https://pmc.ncbi.nlm.nih.gov/articles/PMC10346405/Fisetina atenuează acumularea de senescență celulară în timpul expansiunii culturii celulelor stem derivate din adipos uman

38.https://www.nature.com/articles/s41392-024-01888-z/ Comunicarea celulă-celulă: noi perspective și implicații clinice

39. https://pmc.ncbi.nlm.nih.gov/articles/PMC2915624/Rolul nicotinamidei în deteriorarea ADN-ului, mutageneză și repararea ADN-ului

40. Mdpi.com/2072/8/5/305

Apigenina amelioreaza dislipidemia, steatoza hepatica si rezistenta la insulina prin modularea profilurilor metabolice si transcriptionale in ficatul soarecilor obezi indusi de o dieta bogata in grasimi

41.pubmed.mcbi.nlm.nyh.gov30235452

Fisetina protejeaza impotriva steatozei hepatice non-alcoolice prin reglarea caii de semnalizare SIRT1/AMPK si a beta-oxidarii acizilor grasi la soarecii obezxi indusi de o dieta bogat in grasimi

42. pmc.mcbi.nlm.nih.gov/articles/PMC10196175 PQQ

pentru reducerea acumularii de grasime si ameliorarea progresiei obezitatii

43. https://pmc.ncbi.nlm.nih.gov/articles/PMC5707673/ Mecanisme de reglare epigenetică induse de resveratrol

44. https://orthomolecular.org Niacin and Cancer

How vitamin B-3 protects and even helps repair your DNA (2021)

45. https://www.sciencedirect.com/science/article/pii/S2090123224000055 Resveratrol and p53: How are they involved in CRC plasticity and apoptosis (2024)

46. https://www.sciencedirect.com/science/article/abs/pii/S0378517324002059

Fisetin nanoparticles based on cells cycle and apoptosis intervention for the treatment of lymphoma and leukemia (2024)

47. https://www.sciencedirect.com/science/article/pii/S2213231721003037 Apigenin enhances apoptosis induction by 5-fluorouracil through regulation of thymidylate synthase in colorectal cancer cells (2021)

48. https://www.mdpi.com/2073-4409/10/8/1950 Enzymatic Spermine Metabolites Induce Apoptosis Associated with Increase of p53, caspase-3 and miR-34a in Both Neuroblastoma Cells, SJNKP and the N-Myc-Amplified Form IMR5 (2021)

49. https://pmc.ncbi.nlm.nih.gov/articles/PMC4143536/ Pyrroloquinoline Quinone Induces Cancer Cell Apoptosis via Mitochondrial-Dependent Pathway and Down-Regulating Cellular Bcl-2 Protein Expression (2014)

50. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2022.1031438/full Resveratrol activates CD8+ T cells through IL-18 bystander activation in lung adenocarcinoma (2022)

51. https://pmc.ncbi.nlm.nih.gov/articles/PMC11735101/ Tumor cell–derived spermidine promotes a protumorigenic immune microenvironment in glioblastoma via CD8+ T cell inhibition (2024)

52. https://www.cell.com/iscience/fulltext/S2589-0042%2822%2900202-4

Nicotinamide breaks effector CD8 T cell responses by targeting mTOR signaling (2022)

53. https://www.sciencedirect.com/science/article/pii/S0753332218355379

Effect of resveratrol on expression of genes involved thermogenesis in mice and humans (2019)

54. https://www.sciencedirect.com/science/article/abs/pii/S0955286324000032

Spermidina activează termogeneza țesutului adipos prin autofagie și factorul de creștere a fibroblastelor 21 (2024)

55. https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1368949/full

Resveratrol and vascular health: evidence from clinical studies and mechanisms of actions related to its metabolites produced by gut microbiota (2024)

56. https://link.springer.com/article/10.1007/s12272-013-0226-z Inhibition of mitotic clonal expansion mediates fisetin-exerted prevention of adipocyte differentiation in 3T3-L1 cells (2013)

57. https://www.sciencedirect.com/science/article/abs/pii/B9780128144664000136

Chapter 13 - Pyrroloquinoline Quinone: Its Profile, Effects on the Liver and Implications for Health and Disease Prevention

58. https://pubs.rsc.org/en/content/articlelanding/2020/fo/d0fo00949k

Apigenin induced autophagy and stimulated autophagic lipid degradation (2020)

59. https://www.sciencedirect.com/science/article/abs/pii/S0024320519300992

Fisetin ameliorates oxidative stress, inflammation and apoptosis in diabetic cardiomyopathy (2019)

60. https://pubmed.ncbi.nlm.nih.gov/27040154/ Effects of carnosine supplementation on glucose metabolism: Pilot clinical trial (2016)

61. https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.795980/full

Efficacy of Resveratrol Supplementation on Glucose and Lipid Metabolism: A Meta-Analysis and Systematic ReviewUpdated (2022)

62. https://pmc.ncbi.nlm.nih.gov/articles/PMC7369269/ Pyrroloquinoline quinone can prevent chronic heart failure by regulating mitochondrial function (2020)

63. https://www.sciencedirect.com/science/article/pii/S0197018624001323 The flavonoid fisetin reduces multiple physiological risk factors for dementia (2024)

64. https://www.biorxiv.org/content/10.1101/2024.12.04.626625v1.full

Spermidine alleviates depression via control of the stress response (2024)

65. https://pubmed.ncbi.nlm.nih.gov/33228716/ Nicotinamide, a vitamin B3 ameliorates depressive behaviors independent of SIRT1 activity in mice (2020)

66. https://pubmed.ncbi.nlm.nih.gov/25702528/ Pyrroloquinoline quinone against glutamate-induced neurotoxicity in cultured neural stem and progenitor cells (2025)

67. https://www.cambridge.org/core/journals/experimental-results/article/pyrroloquinoline-quinone-influences-intracellular-alphasynuclein-aggregates/99A3C944C752CDA53E9347F27D1C71BC Pyrroloquinoline quinone influences intracellular alpha-synuclein aggregates (2023)

68. https://pubs.acs.org/doi/abs/10.1021/acschemneuro.8b00355 Esterification of PQQ Enhances Blood-Brain Barrier Permeability and Inhibitory Activity against Amyloidogenic Protein Fibril Formation (2018)

69. https://www.tandfonline.com/doi/full/10.4161/pri.4.1.10889 Pyrroloquinoline quinone inhibits the fibrillation of amyloid proteins (2010)

70. https://www.mdpi.com/2227-9059/11/11/2878

An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways (2023)

71. https://kompetenz-statt-demenz.dsgip.de/en/prevention-treatment/micronutrients/spermidine/ The polyamine spermidine and its neuroprotective effect in Alzheimer’s disease

72. https://www.sciencedirect.com/science/article/pii/S0925443914002920

Neuroprotective action of resveratrol (2015)

73. https://www.alzdiscovery.org/uploads/cognitive_vitality_media/Apigenin-Cognitive-Vitality-For-Researchers.pdf Apigenin - Alzheimer disease (2017)

74. https://veriteresveratrol.com/quality/

75. https://www.sciencedirect.com/science/article/pii/S2213453023000964 Apigenin, a natural flavonoid, promotes autophagy and ferroptosis in human endometrial carcinoma Ishikawa cells in vitro and in vivo (2023)

76. https://www.sciencedirect.com/org/science/article/pii/S0327954523001019 Vitamin B3 inhibits apoptosis and promotes autophagy of islet β cells under high glucose stress (2023)

77. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.960601/full Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis (2022)

78. https://www.sciencedirect.com/science/article/pii/S2666459325000095 Protective effects of apigenin in neurodegeneration: An update on the potential mechanisms (2025)

79. https://pubmed.ncbi.nlm.nih.gov/38780001/ Nrf2 activation by pyrroloquinoline quinone inhibits natural aging‐related intervertebral disk degeneration in mice (2024)

80. https://academic.oup.com/stmcls/article/41/7/698/7190776 Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells (2023)

81. https://link.springer.com/article/10.1007/s11010-015-2452-9 Apigenin promotes osteogenic differentiation of human mesenchymal stem cells through JNK and p38 MAPK pathways (2015)

82. https://www.sciencedirect.com/science/article/abs/pii/S0165037821000024 Promising anti- cervical carcinoma and inflammatory agent, Resveratrol targets poly (ADP-ribose) polymerase 1 (PARP-1) induced premature ovarian failure with a potent enzymatic modulatory activity (2021)

83. https://pmc.ncbi.nlm.nih.gov/articles/PMC4211270/ Modulation of mitochondrial function and autophagy mediates carnosine neuroprotection against ischemic brain damage (2015)

86. https://www.mdpi.com/2076-3921/13/5/602 Cellular ROS and Antioxidants: Physiological and Pathological Role (2024)

87. https://www.sciencedirect.com/science/article/abs/pii/S1567576913004074 Autophagy in inflammation, infection, neurodegeneration and cancer (2014)

88. https://www.ncbi.nlm.nih.gov/books/NBK499821/ Apoptosis (2025)

89. https://www.rockefeller.edu/our-scientists/george-e-palade/2451-nobel-prize/ Palade Nobel Prize 1974

90. https://www.mdpi.com/2218-273X/9/5/174 Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential (2019)

91. https://www.sciencedirect.com/science/article/pii/S1319016422001980 Resveratrol treatment modulates several antioxidant and anti-inflammatory genes expression and ameliorated oxidative stress mediated fibrosis in the kidneys of high-fat diet-fed rats (2022)

92. https://pubmed.ncbi.nlm.nih.gov/38293560/ Spermidine improves the antioxidant capacity and morphology of intestinal tissues and regulates intestinal microorganisms in Sichuan white geese (2023)

Green Tea 500mg

1. The antioxidant and pro-oxidant activities of green tea polyphenols: A role in cancer prevention (2010). ScienceDirect

2. Health Welfares of Green Tea: Green Tea Plant and Its Metabolism-Boosting Properties for Weight Loss. Biological Times

3. Green Tea, Lipid Metabolism, and Weight Management: A Systematic Review (2024). Academic Strive

4. A Review of the Role of Green Tea (Camellia sinensis) in Antiphotoaging, Stress Resistance, Neuroprotection, and Autophagy (2019). MDPI

5. Therapeutic Effects of Green Tea Polyphenol (‒)-Epigallocatechin-3-Gallate (EGCG) in Relation to Molecular Pathways Controlling Inflammation, Oxidative Stress, and Apoptosis (2022). MDPI

6. New insights into the mechanisms of polyphenols beyond antioxidant properties; lessons from the green tea polyphenol, epigallocatechin 3-gallate (2014). ScienceDirect

7. Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG): A Time for a New Player in the Treatment of Respiratory Diseases? (2022). MDPI

8. The Comprehensive Role of Epigallocatechin Gallate (EGCG) in Health: Mechanisms, Benefits, and Future Directions (2025). Care for the Aging

9. Epigalocatechin galat (EGCG): proprietăți farmacologice. MDPI

10. Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential. MDPI - Table Data

11. Catechina ceaiului verde, epigalocatechin-3-galat (EGCG): mecanisme, perspective și aplicații clinice. PMC

Hawthorn Berry 100ct 525mg

84. https://www.mdpi.com/2304-8158/11/18/2861

85. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3891531/

Hydro Mag Powder

1.Gröber U, Schmidt J, Kisters K. Magnesium in Prevention and Therapy. Nutrients. 2015;7(9):8199-8226. doi:10.3390/nu7095388

2. Kirkland AE, Sarlo GL, Holton KF. The Role of Magnesium in Neurological Disorders. Nutrients. 2018;10(6):730. doi:10.3390/nu10060730

3. Chiu HY, Yeh TH, Huang YC, Chen PY. Effects of Intravenous and Oral Magnesium on Reducing Migraine: A Meta-analysis of Randomized Controlled Trials. Pain Physician. 2016;19(1):E97-E112.

4. Castiglioni S, Cazzaniga A, Albisetti W, Maier JA. Magnesium and Osteoporosis: Current State of Knowledge and Future Research Directions. Nutrients. 2013;5(8):3022-3033. doi:10.3390/nu5083022

5. Garrison SR, Allan GM, Sekhon RK, Musini VM. Magnesium for skeletal muscle cramps. Cochrane Database Syst Rev. 2020;9(9):CD009402. doi:10.1002/14651858.CD009402.pub3

6. Bohn T, et al. Magnesium absorption from mineral waters with different mineralization levels in comparison to bread and a supplement. Food Nutr Res. 2017;61(1):1384686. doi:10.1080/16546628.2017.1384686

7. de Baaij JHF, Hoenderop JGJ, Bindels RJM. Magnesium in man: implications for health and disease. Physiol Rev. 2015;95(1):1-46. doi:10.1152/physrev.00012.2014

8. Schwalfenberg GK, Genuis SJ. The Importance of Magnesium in Clinical Healthcare. Scientifica (Cairo). 2017;2017:4179326. doi:10.1155/2017/4179326

9.Barbagallo M, Dominguez LJ. Magnesium and type 2 diabetes. World J Diabetes. 2015;6(10):1152-1157. doi:10.4239/wjd.v6.i10.1152

L-Lysine 500mg

(19) Cody J. Hall, Tatiana P. Soares de Costa; Lysine: biosynthesis, catabolism and roles; Wiki Journal of Science, 2018.

Magnesium Chewable